EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.11.32 | codeine + 2-oxoglutarate + O2 |
- |
Papaver somniferum |
morphine + formaldehyde + succinate + CO2 |
- |
? |
1.14.11.32 | codeine + 2-oxoglutarate + O2 |
- |
Papaver orientale |
morphine + formaldehyde + succinate + CO2 |
- |
? |
1.14.11.32 | neopine + 2-oxoglutarate + O2 |
- |
Papaver somniferum |
neomorphine + formaldehyde + succinate + CO2 |
- |
? |
1.14.11.32 | thebaine + 2-oxoglutarate + O2 |
- |
Papaver somniferum |
oripavine + formaldehyde + succinate + CO2 |
- |
? |
1.14.11.32 | thebaine + 2-oxoglutarate + O2 |
- |
Papaver orientale |
oripavine + formaldehyde + succinate + CO2 |
- |
? |
1.14.11.32 | scoulerine + 2-oxoglutarate + O2 |
120% of the activity with codeine |
Papaver somniferum |
3-O-demethylscoulerine + formaldehyde + succinate + CO2 |
- |
? |
1.14.11.32 | thebaine + 2-oxoglutarate + O2 |
25% of the activity with codeine. Alkyl hydroxylation proceeds through a radical mechanism involving an iron-oxo intermediate, followed by the elimination of formaldehyde |
Papaver somniferum |
oripavine + formaldehyde + succinate + CO2 |
- |
? |
1.14.11.32 | (S)-reticuline + 2-oxoglutarate + O2 |
a 1-benzylisoquinoline, O-demethylation, 16.2% of activity with protopine |
Papaver somniferum |
? |
- |
? |
1.14.11.32 | (S)-scoulerine + 2-oxoglutarate + O2 |
a 1-benzylisoquinoline, O-demethylation, 70.4% of activity with protopine |
Papaver somniferum |
? |
- |
? |
1.14.11.32 | (S)-isocorydine + 2-oxoglutarate + O2 |
a aporphine, O-demethylation, 6.1% of activity with protopine |
Papaver somniferum |
? |
- |
? |