EC Number   |
Substrates |
Organism |
Products  |
Reversibility |
|---|
   3.4.21.47 | C2 fragment + H2O |
C-terminal fragment originating from the processing of meningococcal proteases |
Homo sapiens |
? |
- |
? |
| 3.4.21.47 | more |
fragment Bb is the catalytic subunit of the enzyme, isolated Bb is unable to cleave either C3 or C5 |
Homo sapiens |
? |
- |
? |
| 3.4.21.47 | more |
the enzyme is involved in the alternative pathway of human complement |
Homo sapiens |
? |
- |
? |
| 3.4.21.47 | more |
the activation peptide, C5a, possesses potent spasmogenic and chemotactic activity |
Homo sapiens |
? |
- |
? |
| 3.4.21.47 | more |
the enzyme has a very short half-life. Dissociation of the two noncovalently bound subunits proceeds with a half-life of 1-3 min at 37°C under physiological conditions, and this rate increases greatly if regulatory proteins are present. Numerous decay-accelerating proteins are present in plasma and on host cells that bind to the noncatalytic subunit C3b and increase the rate at which the catalytic subunit Bb is released into the medium. Bb loses its enzymatic activity and its ability to bind to C3b upon release. Although C3b is able to rebind Bb and reform the enzyme, the interaction with most decay-accelerating factors also leads to permanent proteolytic interaction of the cell-bound subunit C3b by a fluid-phase protease Factor I. These regulatory events limit cleavage of C3, reduce release of the anaphylatoxin C3a and control the formation of more efficient C5 convertase enzymes |
Homo sapiens |
? |
- |
? |
| 3.4.21.47 | more |
early complement stimulation in trauma patients analyzed, correlation with injury severity, tissue hypoperfusion and worse clinical outcomes identified |
Homo sapiens |
? |
- |
? |
| 3.4.21.47 | more |
C3b binds uniformly to substances on the surface of Escherichia coli K12, whereas it shows a bimodal distribution on the surface of Staphylococcus aureus P209. Autoactivation activity of C3 |
Tachypleus tridentatus |
? |
- |
? |
| 3.4.21.47 | neisserial heparin binding antigen + H2O |
also known as GNA2132 (genome-derived Neisseria antigen 2132) |
Homo sapiens |
? |
- |
? |
| 3.4.21.47 | t-butyloxycarbonyl-Gly-L-Leu-L-Ala-L-Arg-thiobenzyl ester |
substrate of enzyme subunit Bb |
Homo sapiens |
? |
- |
? |
| 3.4.21.47 | complement component C3 + H2O |
- |
Homo sapiens |
complement component C3a + complement component C3b |
- |
? |
