EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.7.11.9 | ATP + [Goodpasture antigen-binding protein] |
- |
Homo sapiens |
ADP + [Goodpasture antigen-binding phosphoprotein] |
- |
? |
2.7.11.9 | ATP + [Goodpasture antigen-binding protein] |
autophosphorylation via the enzyme's serine/threonine kinase activity that specifically targets a motif in the NC1 domain of the alpha3 chain of type IV collagen, the Good pasture autoantigen |
Homo sapiens |
ADP + [Goodpasture antigen-binding phosphoprotein] |
- |
? |
2.7.11.9 | ATP + [Goodpasture antigen-binding protein] |
autophosphorylation via the enzyme's serine/threonine kinase activity that specifically targets a motif in the NC1 domain of the alpha3 chain of type IV collagen, the Good pasture autoantigen, the enzyme is involved in autoimmune processes and disease |
Homo sapiens |
ADP + [Goodpasture antigen-binding phosphoprotein] |
- |
? |
2.7.11.9 | more |
disruption of the nonvesicular ceramide transport is detrimental to normal embryonic development of somites and brain because of increased apoptosis mediated by the CERT function of GBPB, but not GBPBDELT26, overview |
Danio rerio |
? |
- |
? |
2.7.11.9 | ATP + goodpasture antigen |
enzyme is involved in autoimmune pathogenesis. Enzyme expression is up-regulated in the striated muscle of a Goodpasture patient and in other autoimmune conditions including cutaneous lupus erythematosus, pemphigoid, and lichen planus |
Homo sapiens |
ADP + phosphorylated goodpasture antigen |
- |
? |
2.7.11.9 | more |
Goodpasture antigen-binding protein binds to human serum amyloid P component specifically in its physiological conformations, i.e. pentamers and decamers. Collagen IV binds to serum amyloid P and to Goodpasture antigen-binding protein, the latter also binds laminin, binding studies and kinetics, overview |
Homo sapiens |
? |
- |
? |
2.7.11.9 | ATP + membrane type IV collagen |
Goodpasture-antigen binding protein, GPBP, is a nonconventional Ser/Thr kinase for basement membrane type IV collagen. The 77-kDa GPBP is a soluble extracellular protein that interacts with type IV collagen |
Homo sapiens |
ADP + phopshorylated membrane type IV collagen |
- |
? |
2.7.11.9 | ATP + membrane type IV collagen |
GPBP serves as transporter of ceramide between the endoplasmic reticulum and the Golgi apparatus. The 91-kDa GPBP splicing variants regulates the levels of 77-kDa GPBP variant, i.e. GPBPDELTA26/CERT, in the extracellular compartment |
Homo sapiens |
ADP + phopshorylated membrane type IV collagen |
- |
? |
2.7.11.9 | more |
GPBP-1 targets the GPBP-interacting protein of 130 kDa, GIP130, which binds to myosin and promotes its myofibrillar assembly |
Mus musculus |
? |
- |
? |
2.7.11.9 | more |
isozyme GPBP also function as ceramide transfer proteins, CERT |
Danio rerio |
? |
- |
? |