EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
6.5.1.2 | NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m |
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA |
Aquifex aeolicus |
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m |
- |
? |
6.5.1.2 | NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m |
- |
Aquifex aeolicus VF5 |
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m |
- |
? |
6.5.1.2 | NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m |
- |
Aquifex pyrophilus |
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m |
- |
? |
6.5.1.2 | NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m |
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA |
Aquifex pyrophilus |
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m |
- |
? |
6.5.1.2 | NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m |
joining of a single-strand-scission in double-stranded DNA |
Bacillus amyloliquefaciens |
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m |
- |
? |
6.5.1.2 | NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m |
bacteriophage T5 DNA, which contains single strand interruptions at defined positions in one of the complementary strands |
Bacillus amyloliquefaciens |
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m |
- |
? |
6.5.1.2 | ATP + 5'-phosphate terminus of deoxyribonucleotides |
- |
Bacillus subtilis |
? |
- |
? |
6.5.1.2 | NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m |
- |
Bacillus subtilis |
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m |
- |
? |
6.5.1.2 | NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m |
DNA ligase requires two DNA termini, the 5'-terminus, carrying a phosphate group, and the 3'-terminus, a hydroxyl group. These termini must reside on a double-stranded molecule, DNA:DNA or DNA:RNA. Both strands of the duplex may terminate, in the form of a staggered end or a blunt end, and the ligase then requires a second similar double-stranded terminus to join the two in an intermolecular reaction. Alternatively, the two termini may be provided by a nick in just one strand of a duplex, which the enzyme will then seal |
Bacillus subtilis |
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m |
- |
? |
6.5.1.2 | NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m |
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA |
Bacillus subtilis |
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m |
- |
? |