EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
6.3.1.8 | gamma-L-Glu-L-Cys-Gly + spermidine + ATP |
- |
Crithidia fasciculata |
N1-(gamma-L-Glu-L-Cys-Gly)-spermidine + ADP + phosphate |
- |
? |
6.3.1.8 | gamma-L-Glu-L-Cys-Gly + spermidine + MgATP2- |
- |
Crithidia fasciculata |
N1-(gamma-L-Glu-L-Cys-Gly)-spermidine + MgADP- + phosphate |
- |
? |
6.3.1.8 | gamma-L-Glu-L-Cys-Gly + spermidine + MgATP2- |
substitution of the glycine part abolishes activity |
Crithidia fasciculata |
N1-(gamma-L-Glu-L-Cys-Gly)-spermidine + MgADP- + phosphate |
- |
? |
6.3.1.8 | gamma-L-Glu-L-Ile-Gly + spermidine + ATP |
at 70% of the activity with gamma-L-Glu-L-Cys-Gly |
Crithidia fasciculata |
N1-(gamma-L-Glu-L-Ile-Gly)-spermidine + ADP + phosphate |
- |
? |
6.3.1.8 | gamma-L-Glu-L-Val-Gly + spermidine + ATP |
at 88% of the activity with gamma-L-Glu-L-Cys-Gly |
Crithidia fasciculata |
N1-(gamma-L-Glu-L-Val-Gly)-spermidine + ADP + phosphate |
- |
? |
6.3.1.8 | gamma-L-Glutamyl-L-cysteinyl-glycine + spermidine + ATP |
synthesis of trypanothione, which is involved in maintaining intracellular thiol redox and in defense against oxidants |
Crithidia fasciculata |
? |
- |
? |
6.3.1.8 | gamma-L-Glutamyl-L-cysteinyl-glycine + spermidine + ATP |
key enzyme that participates in the first of two similar steps of trypanothione biosynthesis |
Escherichia coli |
? |
- |
? |
6.3.1.8 | gamma-L-Glutamyl-L-cysteinyl-glycine + spermidine + ATP |
the enzyme is involved in the biosynthesis of the trypanosomatid-specific dithiol trypanothione |
Crithidia fasciculata |
? |
- |
? |
6.3.1.8 | glutathione + spermidine + ATP |
- |
Crithidia fasciculata |
glutathionylspermidine + ADP + phosphate |
- |
? |
6.3.1.8 | glutathione + spermidine + ATP |
- |
Escherichia coli |
glutathionylspermidine + ADP + phosphate |
- |
? |