EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   4.6.1.13 | 1-phosphatidyl-1D-myo-inositol |
Trp-47 and Trp-242 residues are important for enzyme to bind to interfaces, both activating zwitterionic and substrate anionic surfaces, micellar phosphatidylinositol is a better substrate than monomeric phosphatidylinositol |
Bacillus thuringiensis |
1D-myo-inositol 1,2-cyclic phosphate + diacylglycerol |
a cyclic phosphodiesterase activity of PI-PLC converts 1D-myo-inositol 1,2-cyclic phosphate to inositol 1-phosphate |
? |
| 4.6.1.13 | 1-phosphatidyl-1D-myo-inositol |
natural aggregate substrate, PI-PLC is a virulence factor of the animal and human pathogen |
Listeria monocytogenes |
1D-myo-inositol 1,2-cyclic phosphate + diacylglycerol |
- |
? |
| 4.6.1.13 | 1-phosphatidyl-1D-myo-inositol |
natural aggregate substrate, two-site enzyme model with interfacial cooperativity between the active site and a lipid-binding subsite, presumably adjacent to the active site |
Listeria monocytogenes |
1D-myo-inositol 1,2-cyclic phosphate + sn-1,2-diacylglycerol |
- |
? |
| 4.6.1.13 | 1-phosphatidyl-1D-myo-inositol |
- |
Oryza sativa |
1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol |
- |
? |
| 4.6.1.13 | 1-phosphatidyl-1D-myo-inositol |
- |
Bacillus thuringiensis |
1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol |
- |
? |
| 4.6.1.13 | 1-phosphatidyl-1D-myo-inositol |
- |
Bacillus thuringiensis N168C |
1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol |
- |
? |
| 4.6.1.13 | butyl-fluorescein myo-inositol phosphate |
two substrate molecules bind to enzyme, one at the active site and one at a subsite, causing an increase in activity, subsite interactions of PI-PLC |
Bacillus cereus |
D-myo-inositol 1,2-cyclic phosphate + butyl-fluorescein |
- |
? |
| 4.6.1.13 | dibutyrylphosphatidylinositol |
is a poor substrate, necessitating long incubation times (2 to 5 h) if the same enzyme concentration is to be used in the absence and presence of salts and amphiphiles |
Listeria monocytogenes |
1D-myo-inositol 1,2-(cyclic)-phosphate + 1,2-dibutyryl-sn-glycerol |
- |
? |
| 4.6.1.13 | dihexanoylphosphatidyl inositol |
- |
Streptomyces antibioticus |
? |
- |
? |
| 4.6.1.13 | dihexanoylphosphorothioyl-myo-inositol |
- |
Streptomyces antibioticus |
myo-inositol cis(2-OH,S)-1,6-cyclic phosphorothioate + 1,2-dihexanoyl-sn-glycerol |
- |
? |
