EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
  4.2.3.130 | all-trans-heptaprenyl diphosphate |
- |
Bacillus subtilis |
tetraprenyl-beta-curcumene + diphosphate |
tetraprenyl-beta-curcumene shows nonenzymatic autooxidation to tetraprenyl-alpha-curcumene |
? |
| 4.2.3.130 | all-trans-heptaprenyl diphosphate |
- |
Priestia megaterium 168 |
tetraprenyl-beta-curcumene + diphosphate |
- |
? |
| 4.2.3.130 | all-trans-heptaprenyl diphosphate |
- |
Priestia megaterium 319 |
tetraprenyl-beta-curcumene + diphosphate |
- |
? |
| 4.2.3.130 | all-trans-heptaprenyl diphosphate |
- |
Bacillus atrophaeus 1942 |
tetraprenyl-beta-curcumene + diphosphate |
- |
? |
| 4.2.3.130 | more |
Bcl-TS is a sesterterpene (C25)/triterpene (C30) synthase, the enzyme catalyzes the conversion of (all-E)-geranylfarnesyl diphosphate (GFPP) and (all-E)-hexaprenyl diphosphate (HexPP) into beta-geranylfarnesene and beta-hexaprene in a head-to-tail triterpene synthase. NMR spectroscopic and TLC analysis of radiolabeled products, overview. Enzyme Bcl-TS can accept HepPP (C35) as a substrate and cyclizes HepPP (C35) to a monocycle |
Alkalihalobacillus clausii |
? |
- |
? |
| 4.2.3.130 | more |
onoceroids are synthesized from squalene via an intermediate cyclized from one terminus, such as 8alpha-hydroxypolypoda-13,17,21-triene, by cyclization at both termini. Enzyme BmeTC may have single active site: it starts with the initial cascade leading to the bicyclic intermediate 8alpha-hydroxypolypoda-13,17,21-triene from squalene, then turns molecule 8alpha-hydroxypolypoda-13,17,21-triene outside of the active site cavity, and again uptake 8alpha-hydroxypolypoda-13,17,21-triene to catalyze the formation of additional bicyclic and tricyclic structures of onoceranoxide and 14beta-hydroxyonocera-8(26)-ene on the other side of 8alpha-hydroxypolypoda-13,17,21-triene. BmeTC is not only a bifunctional terpene cyclase which converts tetraprenyl-beta-curcumene and squalene into baciterpenol A and 8alpha-hydroxypolypoda-13,17,21-triene but also an onoceroid synthase that catalyzes the convertion of 8alpha-hydroxypolypoda-13,17,21-triene into onoceranoxide and 14beta-hydroxyonocera-8(26)-ene. GC-MS product analysis, overview |
Priestia megaterium |
? |
- |
? |
| 4.2.3.130 | squalene |
- |
Priestia megaterium |
8alpha-hydroxypolypoda-13,17,21-triene |
- |
? |
| 4.2.3.130 | tetraprenyl-beta-curcumene + H2O |
- |
Priestia megaterium |
baciterpenol A |
- |
? |
