EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.21.B26 | osteopontin + H2O |
the enzyme (PC5/6A) efficiently and completely cleaves human osteopontin into three distinct fragments migrating at about 50 kDa, about 18 kDa, and 16 kDa, with evidence for the predicted cleavage sites being at 168RSKSKKFR175-/- and 241KQSR244-/-. PC5/6 also partially cleaves mouse osteopontin to release fragments of about 30 kDa and 29 kDa |
Mus musculus |
? |
- |
? |
| 3.4.21.B26 | PCSK9 + H2O |
PC5/6A inactivates PCSK9 by cleavage at the motif RFHR218 |
Homo sapiens |
PCSK9-DELTAN218 + ? |
- |
? |
| 3.4.21.B26 | PCSK9 + H2O |
- |
Mus musculus |
truncated PCSK9-DELTAN218 + ? |
- |
? |
| 3.4.21.B26 | pGlu-Arg-Thr-Lys-Arg-methyl-7-amido-4-methylcoumarin + H2O |
- |
Homo sapiens |
? |
- |
? |
| 3.4.21.B26 | preprohepcidin + H2O |
key role of the convertases furin, PACE4, PC5 and/or PC7 in the generation and secretion of active hepcidin |
Mus musculus |
? |
- |
? |
| 3.4.21.B26 | pro-cocaine- and amphetamine-regulated transcript precursor + H2O |
PC5/6A preferentially cleaves the pairs of basic sites, KR/KK, of the CART precursor isoforms |
Mus musculus |
bioactive pro-cocaine- and amphetamine-regulated transcript I + bioactive pro-cocaine- and amphetamine-regulated transcript II + ? |
- |
? |
| 3.4.21.B26 | pro-integrin-alpha5 + H2O |
cleavage of the substrate into its heavy and light chains |
Homo sapiens |
active integrin-alpha5 + ? |
- |
? |
| 3.4.21.B26 | pro-integrin-alphaV + H2O |
cleavage of the substrate into its heavy and light chains |
Homo sapiens |
active integrin-alphaV + ? |
- |
? |
| 3.4.21.B26 | pro-von Willebrand factor + H2O |
- |
Mus musculus |
von Willebrand factor + ? |
- |
? |
| 3.4.21.B26 | proform bone morphogenetic protein-2 + H2O |
- |
Homo sapiens |
mature bone morphogenetic protein-2 + ? |
- |
? |
