EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
3.4.21.B26 | ANKKPPLPKRVRRQIHATPTP + H2O |
a peptide representing alpha-dystroglycan amino acids 299-319 that encompasses the predicted PC6-cleavage site (ANKKPPLPKRVRR312-/-QIHATPTP) |
Homo sapiens |
ANKKPPLPKRVRR + QIHATPTP |
- |
? |
3.4.21.B26 | endothelial lipase + H2O |
- |
Mus musculus |
? |
- |
? |
3.4.21.B26 | human immunodeficiency virus type 1 Vpr + H2O |
undergoes proteolytic processing at a very well conserved proprotein convertase cleavage site, R85QRR88-/-, proprotein convertases PC5 and PACE4 can efficiently process extracellular Vpr |
Mus musculus |
? |
- |
? |
3.4.21.B26 | Lefty protein + H2O |
- |
Mus musculus |
? |
- |
? |
3.4.21.B26 | more |
no substrate: amyloid-beta precursor protein |
Mus musculus |
? |
- |
? |
3.4.21.B26 | more |
both isoforms can cleave a number of fluorogenic substrates of general formula Arg/Lys-(Xaa)n-(Arg)-, where n= 2, 4, or 6 |
Homo sapiens |
? |
- |
? |
3.4.21.B26 | more |
death at birth of the PC5/6-deficient embryos |
Mus musculus |
? |
- |
? |
3.4.21.B26 | more |
substrate cleavage analysis. Strong preference of Arg at position P1 and P4 |
Homo sapiens |
? |
- |
? |
3.4.21.B26 | more |
development of a high-throughput immunohistochemic assay for human proprotein convertase 5/6 for detecting uterine receptivity, method evaluation, overview |
Homo sapiens |
? |
- |
? |
3.4.21.B26 | osteopontin + H2O |
Pcsk5/PCSK5 is temporally and spatially expressed with Opn/OPN (Spp1/SPP1) in osteoblasts and osteocytes, indicating that osteopontin could be a physiologically relevant substrate for PC5/6 or PC5/6-activated proteases in bone. Cleavage of osteopontin may modify the function of osteopontin in bone and/or modulate other enzymatic cleavages of osteopontin, leading to alterations in the bone phenotype |
Mus musculus |
? |
- |
? |