EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.21.92 | Sda + H2O |
ClpXP, VSS at C-terminal as degradation tag |
Bacillus subtilis |
? |
- |
? |
| 3.4.21.92 | SpollAB + H2O |
ClpCP, LCN at C-terminal as degradation tag, MecA not required, production of ClpP is strongly increased in response to heat shock or other stress signals, ClpP removes heat damaged proteins |
Bacillus subtilis |
? |
- |
? |
| 3.4.21.92 | Spx + H2O |
ClpCP, MecA or YpbH required for degradation |
Bacillus subtilis |
? |
- |
? |
| 3.4.21.92 | Spx + H2O |
ClpXP, LAN at C-terminal as degradation tag, MecA not required |
Bacillus subtilis |
? |
- |
? |
| 3.4.21.92 | SsrA tagged proteins + H2O |
ClpXP, AA at C-terminal as degradation tag |
Bacillus subtilis |
? |
- |
? |
| 3.4.21.92 | ssrA-dabsyl + H2O |
initial rate of degradation of this intermediate-sized substrate is 3fold faster with ClpAP as compared to wild-type Clp and 5fold faster with ClpPDELTAN as compared to wild-type ClpP |
Escherichia coli |
? |
- |
? |
| 3.4.21.92 | SsrA-tagged LacZ + H2O |
both proteolytic subunits ClpP1 and ClpP2 degrade SsrA-tagged LacZ |
Mycobacterium tuberculosis |
? |
- |
? |
| 3.4.21.92 | SsrA-tagged LacZ + H2O |
both proteolytic subunits ClpP1 and ClpP2 degrade SsrA-tagged LacZ |
Mycobacterium tuberculosis H37Rv |
? |
- |
? |
| 3.4.21.92 | stalk synthesis transcription factor TacA + H2O |
TacA degradation is controlled during the cell cycle dependent on the ClpXP regulator CpdR and stabilization of TacA increases degradation of another ClpXP substrate, CtrA, while restoring deficiencies associated with prolific CpdR activity |
Caulobacter vibrioides |
? |
- |
? |
| 3.4.21.92 | Starvation proteins + H2O |
the ClpP proteolytic subunit plays a subtle but important role when cells are recovering from starvation. This enzyme is important in the selective degradation of starvation proteins when growth resumes |
Escherichia coli |
? |
- |
? |
