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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47complement component C3 zymogen + H2O - Homo sapiens complement component C3b + complement component C3a - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47complement component C3 zymogen + H2O activation Homo sapiens complement component C3b + complement component C3a - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47complement component C5 + H2O - Homo sapiens complement component C5a + complement component C5b - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47complement component C5 + H2O methionine-modified enzyme has significantly lower C5-cleavage ability than that of unmodified enzyme Homo sapiens complement component C5a + complement component C5b - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47complement component C5 zymogen + H2O - Homo sapiens complement component C5b + complement component C5a - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47complement component C5 zymogen + H2O activation Homo sapiens complement component C5b + complement component C5a - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47more fragment Bb is the catalytic subunit of the enzyme, isolated Bb is unable to cleave either C3 or C5 Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47more the enzyme is involved in the alternative pathway of human complement Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47more the activation peptide, C5a, possesses potent spasmogenic and chemotactic activity Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47more the enzyme has a very short half-life. Dissociation of the two noncovalently bound subunits proceeds with a half-life of 1-3 min at 37°C under physiological conditions, and this rate increases greatly if regulatory proteins are present. Numerous decay-accelerating proteins are present in plasma and on host cells that bind to the noncatalytic subunit C3b and increase the rate at which the catalytic subunit Bb is released into the medium. Bb loses its enzymatic activity and its ability to bind to C3b upon release. Although C3b is able to rebind Bb and reform the enzyme, the interaction with most decay-accelerating factors also leads to permanent proteolytic interaction of the cell-bound subunit C3b by a fluid-phase protease Factor I. These regulatory events limit cleavage of C3, reduce release of the anaphylatoxin C3a and control the formation of more efficient C5 convertase enzymes Homo sapiens ? - ?
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