EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.21.47 | complement component C5 zymogen + H2O |
activation |
Homo sapiens |
complement component C5b + complement component C5a |
- |
? |
| 3.4.21.47 | neisserial heparin binding antigen + H2O |
also known as GNA2132 (genome-derived Neisseria antigen 2132) |
Homo sapiens |
? |
- |
? |
| 3.4.21.47 | complement component C3 + H2O |
analysis of structure and function of complement component C3b in complex with the macrophage-expressed complement receptor CRIg, CRIg shown as an inhibitor of alternative complement convertases |
Homo sapiens |
complement component C3a + complement component C3b |
- |
? |
| 3.4.21.47 | C2 fragment + H2O |
C-terminal fragment originating from the processing of meningococcal proteases |
Homo sapiens |
? |
- |
? |
| 3.4.21.47 | more |
C3b binds uniformly to substances on the surface of Escherichia coli K12, whereas it shows a bimodal distribution on the surface of Staphylococcus aureus P209. Autoactivation activity of C3 |
Tachypleus tridentatus |
? |
- |
? |
| 3.4.21.47 | complement component C3 + H2O |
cleavage of complement component C3 mediated through the MBL pathway in human serum analyzed, mannan-binding lectin (MBL) promotes activation of C3, combined action of MBL-associated serine proteases MASP-1 and MASP-2 required, involvement of the alternative pathway not detected |
Homo sapiens |
complement component C3a + complement component C3b |
- |
? |
| 3.4.21.47 | complement component C3 + H2O |
cleavage of complement component C3 through the mannan-binding lectin pathway in mouse sera determined |
Mus musculus |
complement component C3a + complement component C3b |
- |
? |
| 3.4.21.47 | complement component C3 + H2O |
complement activation in properdin-deficient mice analyzed |
Mus musculus |
complement component C3a + complement component C3b |
- |
? |
| 3.4.21.47 | complement component C3 + H2O |
complement component C3 is the preferred substrate. Cleavage of the preferred C3 substrate and deposition of C3b effectively switches the output of the enzyme from C3b to C5b, resulting in initiation of the cytosolic process of complement |
Homo sapiens |
complement component C3a + complement component C3b |
- |
? |
| 3.4.21.47 | more |
early complement stimulation in trauma patients analyzed, correlation with injury severity, tissue hypoperfusion and worse clinical outcomes identified |
Homo sapiens |
? |
- |
? |
