EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.3.1.B41 | more |
sirtuin6 performs H3K9 acetylation on histone H3, cf. EC 2.3.1.286 |
Homo sapiens |
? |
- |
- |
2.3.1.B41 | more |
a myristoyl peptide and a palmitoyl peptide are incubated with sirtuin6. Sirtuin6 exhibits both SIRT6 deacetylase and deacylase activities, cf. EC 2.3.1.286 |
Homo sapiens |
? |
- |
- |
2.3.1.B41 | more |
SIRT6 can undergo intramolecular mono-ADP-ribosylation utilizing NAD+ as a substrate, i.e. mono-ADP-ribosylation. SIRT6 also performs ADP-ribosyl transferase activity on other protein substrates, overview. Weak deacetylase activity of SIRT6 in vitro |
Homo sapiens |
? |
- |
- |
2.3.1.B41 | more |
SIRT6 can undergo intramolecular mono-ADP-ribosylation utilizing NAD+ as a substrate. Purified mouse SIRT6 successfully catalyzes the transfer of radiolabel from [32P]NAD+ onto itself, i.e. mono-ADP-ribosylation. also performs ADP-ribosyl transferase activity on other protein substrates, overview. Weak deacetylase activity of SIRT6 in vitro |
Mus musculus |
? |
- |
- |
2.3.1.B41 | more |
Sirt6-dependent deacetylation of H3K18 and H3K9 in a histone protein preparation and in HeLa nucleosomes |
Homo sapiens |
? |
- |
- |
2.3.1.B41 | NAD+ + Ac-AK(N6-acetyl)K-7-amido-4-methylcoumarin |
the substrate is based on the human tumour suppressor protein p53 |
Homo sapiens |
nicotinamide + Ac-AKK-7-amido-4-methylcoumarin + 2'-O-acetyl-ADP-ribose |
- |
? |
2.3.1.B41 | NAD+ + Ac-HK(N6-acetyl)K-7-amido-4-methylcoumarin |
the substrate is based on the human tumour suppressor protein p53 |
Homo sapiens |
nicotinamide + Ac-HKK-7-amido-4-methylcoumarin + 2'-O-acetyl-ADP-ribose |
- |
? |
2.3.1.B41 | NAD+ + Ac-RHK(N6-acetyl)K-7-amido-4-methylcoumarin |
the substrate is based on the amino acids 379-382 of the human tumour suppressor protein p53 |
Homo sapiens |
nicotinamide + Ac-RHKK-7-amido-4-methylcoumarin + 2'-O-acetyl-ADP-ribose |
- |
? |
2.3.1.B41 | NAD+ + Ac-RYQ(N6-acetyl)K-7-amido-4-methylcoumarin |
the peptide substrate mimics the biological deacetylation site of histone H3 K56 |
Homo sapiens |
nicotinamide + Ac-RYQK-7-amido-4-methylcoumarin + 2'-O-acetyl-ADP-ribose |
- |
? |
2.3.1.B41 | NAD+ + Ac-TAR(N6-acetyl)K-7-amido-4-methylcoumarin |
the peptide substrate mimics the biological deacetylation site of histone H3 K9 |
Homo sapiens |
nicotinamide + Ac-TARK-7-amido-4-methylcoumarin + 2'-O-acetyl-ADP-ribose |
- |
? |