EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.8.4.13 | more |
methionine sulfoxide reduction pathway, overview |
Escherichia coli B |
? |
- |
? |
1.8.4.13 | more |
possible pathway, overview |
Saccharomyces cerevisiae |
? |
- |
? |
1.8.4.13 | more |
the enzyme might act in vivo on the free methionine sulfoxide substrate or on protein-bound methionine sulfoxide residues |
Escherichia coli K-12 |
? |
- |
? |
1.8.4.13 | more |
substrate specificity, overview, Mem-R,S-Msr can also catalyze the reduction of L-methionine (R)-sulfoxide, EC 1.8.4.14, enzyme reduces oxidized methionine residues of the ribosomal protein L12, which becomes reversibly inactivated and forms monomers instead of dimers upon oxidation |
Escherichia coli |
? |
- |
? |
1.8.4.13 | more |
the purified enzyme may contain thioredoxin |
Saccharomyces cerevisiae |
? |
- |
? |
1.8.4.13 | more |
no activity with peptide-L-methionine-(S)-S-oxide |
Escherichia coli |
? |
- |
? |
1.8.4.13 | more |
the enzyme might act in vivo on the free methionine sulfoxide substrate or on protein-bound methionine sulfoxide residues |
Escherichia coli K-12 2276 |
? |
- |
? |
1.8.4.13 | N-acetyl-L-methionine (S)-sulfoxide + thioredoxin |
membrane-bound enzyme form Mem-R,S-Msr |
Escherichia coli |
N-acetyl-L-methionine + thioredoxin disulfide + H2O |
- |
? |
1.8.4.13 | sulindac + NADPH |
activation of a methionine sulfoxide-containing prodrug, activity with membrane-bound enzyme form Mem-R,S-Msr |
Escherichia coli |
sulindac sulfide + NADP+ + H2O |
activated drug which inhibits cyclooxygenase 1 and 2 and exhibits anti-inflammatory activity |
? |
1.8.4.13 | sulindac + NADPH |
activity with membrane-bound enzyme form Mem-R,S-Msr |
Escherichia coli |
sulindac sulfide + NADP+ + H2O |
- |
? |