EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.14.B11 | nicotine + O2 + [reduced NADPH-hemoprotein reductase] + O2 |
- |
Nicotiana tabacum |
nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |
1.14.14.B11 | nicotine + [reduced NADPH-hemoprotein reductase] + O2 |
- |
Homo sapiens |
nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |
1.14.14.B11 | nicotine + [reduced NADPH-hemoprotein reductase] + O2 |
- |
Nicotiana tabacum |
nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |
1.14.14.B11 | nicotine + [reduced NADPH-hemoprotein reductase] + O2 |
- |
Nicotiana tomentosiformis |
nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |
1.14.14.B11 | nicotine + [reduced NADPH-hemoprotein reductase] + O2 |
- |
Nicotiana sylvestris |
nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |
1.14.14.B11 | nicotine + [reduced NADPH-hemoprotein reductase] + O2 |
- |
Nicotiana tabacum |
nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O |
isoform CYP82E4v1 is responsible for the conversion of nicotine to nornicotine |
? |
1.14.14.B11 | nicotine + [reduced NADPH-hemoprotein reductase] + O2 |
nornicotine is a secondary tobacco alkaloid that is produced by the N-demethylation of nicotine. Nornicotine production and accumulation in tobacco are undesirable because nornicotine serves as the precursor in the synthesis of the carcinogen N-nitrosonornicotine during the curing and processing of tobacco |
Nicotiana tabacum |
nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |