Search Substrates and Products (Substrate)

2.7.11.10

ATP + a protein

autophosphorylation at both Ser and Thr

ADP + a phosphoprotein

?

2.7.11.10

ATP + a protein

CHUK associates with the NF-kappaB inhibitory protein, IkappaB-alpha, in mammalian cells. CHUK specifically phosphorylates IkappaB-alpha on both Ser32 and Ser36, modifications that are required for targeted degradation of IkappaB-alpha via the ubiquitin-proteasome pathway

ADP + a phosphoprotein

?

2.7.11.10

ATP + a protein

the I kappa B/NF-kappa B system is a key determinant of mucosal inflammation and protection

ADP + a phosphoprotein

2.7.11.10

ATP + a protein

the I kappa B/NF-kappa B system is a key determinant of mucosal inflammation and protection

ADP + a phosphoprotein

2.7.11.10

ATP + a protein

the expression of pkn1 is developmentally regulated to start immediately before spore formation. The enzyme plays an important role in the onset of proper differentiation

ADP + a phosphoprotein

?

2.7.11.10

ATP + a protein

phosphorylation of IkappaBs marks them out for destruction, thereby relieving their inhibitory effect on NF-kappaB

ADP + a phosphoprotein

?

2.7.11.10

ATP + a protein

phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses

ADP + a phosphoprotein

?

2.7.11.10

ATP + a protein

phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses

ADP + a phosphoprotein

?

2.7.11.10

ATP + Bcl

phosphorylation at the C-terminus of Bcl by IKKbeta disrupts Bcl10/Malt1 association and Bcl10-mediated signaling

ADP + phosphorylated Bcl

?

2.7.11.10

ATP + Bcl

phosphorylation at the C-terminus of Bcl by IKKbeta disrupts Bcl10/Malt1 association and Bcl10-mediated signaling

ADP + phosphorylated Bcl

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