EC Number   |
Source Tissue |
Reference |
|---|
   3.4.23.46 | Alzheimer specific cell type |
metal homeostasis analyzed in |
683143 |
| 3.4.23.46 | astrocyte |
astrocytic BACE1 expression may be important to the development of pathology in Alzheimer's disease |
669930 |
| 3.4.23.46 | B-103 cell |
- |
700849 |
| 3.4.23.46 | blood platelet |
- |
700445, 713114 |
| 3.4.23.46 | blood platelet |
membrane cholesterol significantly influences membrane beta-secretase activity in a biphasic manner, with positive correlations at higher membrane cholesterol levels, and negative correlations at lower membrane cholesterol levels. Platelets from individuals with Alzheimer's disease or mild cognitive impairment are significantly more likely to lie within the negative correlation zone than control platelets |
699657 |
| 3.4.23.46 | brain |
- |
638896, 638909, 669331, 669332, 669344, 669928, 669930, 678539, 683144, 683911, 697348, 698870, 700411, 700416, 700980, 711634, 711918, 711944, 712831, 713117, 733384, 753126, 754384 |
| 3.4.23.46 | brain |
Alzheimer disease brain and control |
683469 |
| 3.4.23.46 | brain |
Alzheimer disease patients, endogenous processing of beta2 subunit of voltage-gated sodium channel found to be increased |
683908 |
| 3.4.23.46 | brain |
BACE1 expression is decreased in diseased brain |
700980 |
| 3.4.23.46 | brain |
BACE1 is expressed exclusively in neurons but not in glial cells. BACE1 is increased in remaining neurons in Alzheimer's disease brains |
670411 |
