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EC Number Renatured (Commentary) Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.6.4.B10TRiC can refold denatured AML1-175 (DBD) and restore its DNA binding activity in vitro. The reconstructed the TRiC-AML1-175 complex is formed in the presence of Ni2+-gold nanoparticles capable of binding to the His-tag on AML1-175. While AML1-175 is folded by TRiC to achieve its native function, ATP hydrolysis does not suffice to trigger its release from the chaperonin 756197
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