EC Number   |
General Information |
Reference |
|---|
   7.2.2.14 | metabolism |
the enzyme acts as a sensor as well as a transporter of Mg2+ |
750401 |
| 7.2.2.14 | physiological function |
inactivation of magnesium transporter MgtB leads to a reduced growth relative to the wild-type, even in media supplemented with 1 mM Mg2+. MgtB mutants survive equally as well as the respective parent strain within macrophages, although they are more sensitive to killing in the Galleria model of infection. MgtB is required for macrophage invasion in Yersinia pestis. Yersinia MgtB deletion mutants are more highly attenuated than the equivalent Yersinia PhoP two-component regulatory system deletion mutants in mouse models of infection |
734646 |
| 7.2.2.14 | physiological function |
inactivation of magnesium transporter MgtB leads to a reduced growth relative to the wild-type, even in media supplemented with 1 mM Mg2+. MgtB mutants survive equally as well as the respective parent strain within macrophages, although they are more sensitive to killing in the Galleria model of infection. Yersinia MgtB deletion mutants are more highly attenuated than the equivalent Yersinia PhoP two-component regulatory system deletion mutants in mouse models of infection |
734646 |
| 7.2.2.14 | physiological function |
magnesium transporter MgtE inhibits type III secretion system gene expression by stimulating rsmYZ transcription. The translation of the transcriptional activator ExsA is repressed by expression of the enzyme |
750968 |
| 7.2.2.14 | physiological function |
mutants lacking transproter Alr1 activity show sensitivity to deprivation and excess Mg2+ and Ca2+. They also exhibit an autonomous ascospore maturation defect. Mutant ascospores are arrested at an early stage when they contain two nuclei |
733920 |
| 7.2.2.14 | physiological function |
overexpression of Bacillus subtilis MgtE is able to rescue the growth of DT40 B-cells lacking lacking the ion-channel kinase transient receptor potential cation channel, TRPM7. There is no detectable current development in TRPM7-deficient cells expressing MgtE. In DT40 B-cells, MgtE expression is strongly downregulated at high magnesium concentrations. The N-terminal cytoplasmic domain of MgtE is required for normal MgtE channel function |
735067 |
| 7.2.2.14 | physiological function |
overexpression of MagT1 in Transient Receptor Potential Melastatin 7 (TRPM7)-deficient cells augments their capacity to uptake Mg2+, and improves their growth behavior in the absence of excess Mg2+ |
719501 |
| 7.2.2.14 | physiological function |
silencing of MGT6 in transgenic plants by RNA interference results in growth retardation under the low-Mg2+ condition. RNAi plants contain lower levels of Mg2+ compared with wild-type plants under low Mg2+ but not under Mg2+-sufficient conditions. MGT6 plays a key role in Mg2+ uptake by roots under Mg2+ limitation |
734895 |
| 7.2.2.14 | physiological function |
the MgtA protein mediates Mg2+ uptake from the periplasm into the cytoplasm |
719721 |
