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6.3.1.1
evolution
existence of a very significant conservation in active site residues between TbASNA and Escherichia coli AsnA. Asparagine synthetase is an enzyme that catalyzes the synthesis of asparagine from aspartate using ATP as the energy source in the presence of a nitrogen donor. The nitrogen donor can be glutamine or ammonia. Two families of asparagine synthetases are known to date: One is asparagine synthetase A (AsnA), which utilizes nitrogen only from an ammonia source reported from prokaryotes as well as from archaea. The other family is asparagine synthetase B (AsnB) whose members are found in prokaryotes and eukaryotes. Members of the AsnB family preferentially utilize glutamine as the nitrogen source, although they are capable of utilizing both glutamine and ammonia. Although they are eukaryotes, Leishmania and Trypanosoma surprisingly possess both ASNA and ASNB
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745294
6.3.1.1
physiological function
the enzyme is essential for survival of the Leishmania parasite
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745294
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