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5.1.1.15
evolution
the deduced amino acid sequence of ACLR from Ensifer sp. 23-3 exhibits high similarity (99%) to that of aspartate aminotransferase family protein (UniProt ID W8HW01) from Ensifer adhaerens strain OV14
748352
5.1.1.15
evolution
the enzyme belongs to the fold-type I PLP-dependent enzyme family
746781
5.1.1.15
malfunction
the mutation of either Asp210 or Lys267 to alanine abolish the racemization activity for 2-aminohexano-6-lactam
746781
5.1.1.15
more
analysis of the structure-function relationship, overview. Lys241 is a key amino acid residue, active site structure of ACL racemase. The substrate binding site is typically located between Trp49 and Tyr137. Lys241 Nepsilon is considered to be important for recognizing the carbonyl O of the substrate. Lys241 also forms a salt bridge with Glu396. Asp210 and Lys267 are two plausible acid/base catalytic candidate residues, situated on the re and si faces of the pyridoxal 5'-phosphate ring, respectively. The racemization of ACL racemase proceeds via a two-base mechanism
746781
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