EC Number   |
General Information |
Reference |
|---|
    4.6.1.1 | malfunction |
glucose utilization is inhibited in adenylate cyclase deletion mutant CgYA in the presence of acetate |
707244 |
| 4.6.1.1 | malfunction |
inhibition of adenylyl cyclase in amygdala blocks the effect of audiogenic seizure kindling in genetically epilepsy-prone rats |
710099 |
| 4.6.1.1 | malfunction |
knockdown of AC5 and AC6 with siRNA reduces the ability of UDP to decrease cAMP |
707057 |
| 4.6.1.1 | physiological function |
adenylate cyclase plays an essential role in the acetate metabolism of Corynebacterium glutamicum |
707244 |
| 4.6.1.1 | physiological function |
adenylyl cyclase activity is required in early-mid erythrocytic stages and functions as the parasite's pH sensor during growth inside red blood cells |
730701 |
| 4.6.1.1 | physiological function |
cardiac-directed adenylyl cyclase 6 expression attenuates left ventricular hypertrophy and dysfunction in cardiomyopathy. Left ventricular contractility is increased, diastolic function is improved and left ventricular dilation is reduced by activation of adenylyl cyclase 6 expression |
714051 |
| 4.6.1.1 | physiological function |
hyaluronic acid and heparin are physiological glycosaminoglycans capable of inducing in vitro capacitation in cryopreserved bull sperm, stimulating different enzymatic pathways and intracellular signals modulated by a membrane-associated adenylate cyclase. Hyaluronic acid induces sperm capacitation involving LDH and CK activities, thereby reducing oxidative metabolism, and this process is mediated by membrane-associated adenylate cyclase |
746755 |
| 4.6.1.1 | physiological function |
in primary cultures of dentate granule cells transfected with PAC, short-term elevation of intracellular cAMP levels induces axonal branching but not elongation, whereas long-term cAMP elevation induces both axonal branching and elongation. The temporal dynamics of intracellular cAMP levels regulate axonal branching and elongation through the activation of protein kinase A (PKA) and exchange protein directly activated by cAMP, respectively |
749309 |
| 4.6.1.1 | physiological function |
in transgenic myocytes overexpressing the enzyme, the sarcoplasmic reticulum Ca2+ content, fractional Ca2+ release, and twitch Ca2+ transient are significantly higher than in wild-type myocytes. Action potential duration is significantly longer in transgenic cells than in wild-type. Overexpressing myocytes developed spontaneous Ca2+ waves in a larger fraction compared with wild-type, particularly when cells were exposed to isoproterenol. Overexpressing hearts have increased levels of SERCA2a, oxidized Ca2+/calmodulin-dependent protein kinase II, and phosphorylation of ryanodine receptors at the CaMKII site, especially after isoproterenol treatment |
746705 |
| 4.6.1.1 | physiological function |
isoform AC3 is a likely candidate to fulfill an integrative role in sensory, motor and higher-order information processing in the honeybee brain |
715176 |
