EC Number   |
General Information |
Reference |
|---|
    4.1.1.49 | malfunction |
Brucella suis 513 attenuation occurrs only in the double phosphoenolpyruvate carboxykinase (PckA) / pyruvate phosphate dikinase (PpdK) mutant |
-, 761159 |
| 4.1.1.49 | malfunction |
lack of phosphoenolpyruvate carboxykinase leads to activation of AMP-activated protein kinase, which inhibits cAMP-induced steroidogenic gene promoter activity and gene expression |
727933 |
| 4.1.1.49 | metabolism |
Brucella suis 513 used pyruvate phosphate dikinase (PpdK) and phosphoenolpyruvate carboxykinase (PckA) for phosphoenolpyruvate synthesis in vitro |
-, 761159 |
| 4.1.1.49 | physiological function |
both phosphoenolpyruvate carboxykinase and diphosphate-dependent pyruvate phosphate dikinase colocalize with glycolytic enzymes within the glycosomes of Trypanosoma evansi. Both enzymes can make use of PEP for contributing to the production of ATP within the organelles |
747713 |
| 4.1.1.49 | physiological function |
Brucella suis biovar 5 depends on phosphoenolpyruvate carboxykinase and pyruvate phosphate dikinase for full virulence in laboratory models |
-, 761159 |
| 4.1.1.49 | physiological function |
Danio rerio larvae show increased V-ATPase-mediated acid secretion and transient expression of Pck1, in response to acid stress. Pck1 gene knockdown decreases the H+ secretion via V-ATPase, the effect is rescued by supplementation of glucose into the yolk. Pck1 knockdown does not affect glutamine/glutamate catalysis |
747961 |
| 4.1.1.49 | physiological function |
the enzyme is required for steroidogenesis in testicular Leydig cells |
727933 |
