EC Number   |
General Information |
Reference |
|---|
  3.6.1.72 | physiological function |
aprataxin is highly effective as a DNA 3' decapping enzyme, converting DNAppG to DNA3'p and GMP. The biochemical impact of DNA capping is to prevent resection and healing of a 3'-PO4 end, while permitting DNA synthesis, at the price of embedding a ribonucleotide and a diphosphate linkage in the repaired strand |
-, 755244 |
| 3.6.1.72 | physiological function |
aprataxin, implicated in repair of A5'pp5'DNA ends formed during abortive ligation by classic ligases, is highly effective as a DNA 3' decapping enzyme, converting DNAppG to DNA3'p and GMP. The biochemical impact of DNA capping is to prevent resection and healing of a 3'-PO4 end, while permitting DNA synthesis. Aprataxin affords a means to counter the impact of DNA capping |
-, 741333 |
| 3.6.1.72 | physiological function |
APTX suppresses DNA-ligase 11-catalyzed ligation of 8oxoG-containing DNA. In presence of APTX, the catalytic commitment of DNA ligase 1 to erroneous ligation is reduced by 70 and 90%, respectively, for the 8oxoG:A and 8oxoG:C substrates |
754827 |
| 3.6.1.72 | physiological function |
depletion of aprataxin in human SHSY5Y neuroblastoma cells and primary skeletal muscle myoblasts results in mitochondrial dysfunction, revealed by reduced citrate synthase activity and mtDNA copy number. mtDNA, not nuclear DNA, has higher levels of background DNA damage on aprataxin knockdown |
755241 |
