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EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 3.5.2.19malfunction construction of an sttH gene-knockout mutant. The minimum inhibitory concentration MIC of Streptothricins in the sttH gene-knockout mutant is determined to be 6.25 mg/ml, whereas the MIC of streptothricins in the Streptomyces albulus wild strain is determined to be above 400 mg/ml. This result clearly demonstrate that sttH is the sole gene responsible for streptothricin resistance in the Streptomyces albulus strain -, 707008
Display the reaction diagram Show all sequences 3.5.2.19physiological function sttH gene is not essential for growth. The true role of SttH may not be its involvement in resistance against streptothricins, instead, it may catalyze the hydrolysis of naturally occurring cyclic amide compounds in the metabolism of Streptomyces albulus -, 707008
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