EC Number   |
General Information |
Reference |
|---|
   3.4.24.68 | malfunction |
TeNT cleaves vesicle-associated membrane protein-2, thereby inhibiting neurotransmitter release in the central nervous system to elicit spastic paralysis |
709053 |
| 3.4.24.68 | metabolism |
the enzyme cleaves a neuronal soluble N-ethylmaleimide-sensitive attachment receptor protein, leading to the blockade of inhibitory neurotransmitter release and subsequent generalized muscular spasm |
754911 |
| 3.4.24.68 | physiological function |
cleavage of synaptobrevin results in inhibition of release of neurotransmitters glycine and gamma-amino butyric acid from inhibitory interneurons causing spastic paralysis |
707330 |
| 3.4.24.68 | physiological function |
the enzyme is the main cause of tetanus disease |
753215 |
| 3.4.24.68 | physiological function |
the enzyme is the most important virulence factor that plays a key role in the pathogenicity of tetanus |
754630 |
| 3.4.24.68 | physiological function |
the enzyme undergoes binding to specific components of the basal membrane at the neuromuscular junction, is endocytosed into motor neurons and sorted to axonal signaling endosomes. Following this, the enzyme is transported to the soma of motor neurons located in the spinal cord or brainstem, and then transcytosed to inhibitory interneurons, where it blocks synaptic transmission. Enzyme-induced impairment of inhibitory input leads to hyperactivity of motor neurons, causing spastic paralysis |
755603 |
