EC Number   |
General Information |
Reference |
|---|
   3.4.23.15 | metabolism |
renin is the first rate-limiting enzymatic step in the renin-angiotensin-aldosterone system pathway |
712922 |
| 3.4.23.15 | metabolism |
renin is the rate-limiting step in angiotensin II generation |
710823 |
| 3.4.23.15 | physiological function |
renin is a key regulator of the renin-angiotensin system which is important for blood pressure and electrolyte regulation. High renin angiotensin system activity results in over-activation of the angiotensin AT1-receptor by its substrate, angiotensin II, leading to increases in blood pressure and direct growth-promoting effects on tissues that result in end-organ damage |
712265 |
| 3.4.23.15 | physiological function |
renin-catalyzed conversion of angiotensinogen to angiotensin i is the rate-limiting step in the event cascade that activates the renin-angiotensin system. Renin directly increases the production of the fibrogenic cytokine transforming growth factor beta1 in the kidney |
713093 |
| 3.4.23.15 | physiological function |
the intrarenal renin-angiotensin-aldosterone system is activated and plays a critical role in the pathogenesis of chronic kidney disease |
711686 |
| 3.4.23.15 | physiological function |
the renin-angiotensin-aldosterone system plays a key role in the regulation of blood volume, blood pressure, and cardiovascular and renal function |
712875 |
