EC Number   |
General Information |
Reference |
|---|
   3.4.22.58 | malfunction |
caspase-5 knockdown by shRNA reduces caspase-1 protein expression and activation and inhibited TNF-alphainduced interleukin-8 and MCP-1 |
717689 |
| 3.4.22.58 | physiological function |
caspase-4 and caspase-5 are the key determinants of one-step inflammasome activation in human monocyte. The contribute to TLR4-mediated IL-1alpha/beta release from human monocytes |
754835 |
| 3.4.22.58 | physiological function |
caspase-5 is an initiator caspase of proinflammatory and apoptotic pathways induced by vaccinia infection. The processing of a short vaccinia virus-encoded antigen can take place by a proteasome-independent pathway involving initiator caspase-5 and -10, which generate antigenic peptides recognized by CD8+ T lymphocytes. Each enzyme can use the degradation products of the other as substrate for new cleavages, indicating concerted endoproteolytic activity of caspase-5 and -10, EC 3.4.22.58 and EC 3.4.22.63 |
717823 |
| 3.4.22.58 | physiological function |
caspase-5 rescues UVB-dependent IL-1beta activity in apoptosis-associated speck-like protein containing a CARD (ASC)-deficient epidermal keratinocyte |
755005 |
| 3.4.22.58 | physiological function |
functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells. Involvement of caspase-5 in tunicamycin-induced apoptotic cell death, similar to caspase-4, EC 3.4.22.57 |
717689 |
| 3.4.22.58 | physiological function |
membrane vesicles from Pseudomonas aeruginosa activate the noncanonical inflammasome in human monocytes through caspase-5 |
753785 |
