3.1.2.32 | physiological function |
in biosynthesis of the alkylquinolones 2-heptyl-3-hydroxy-4(1H)-quinolone and 2-heptyl-4(1H)-quinolone, PqsE acts as thioesterase, hydrolyzing the biosynthetic intermediate 2-aminobenzoylacetyl-coenzyme A to form 2-aminobenzoylacetate, the precursor of 2-heptyl-4(1H)-quinolone and 2-aminoacetophenone. The role of PqsE can be taken over to some extent by the broad-specificity thioesterase TesB. A pqsE mutant produces increased levels of 2,4-dihydroxyquinoline, resulting from intramolecular cyclization of 2-aminobenzoylacetyl-coenzyme A |
-, 738043 |