EC Number   |
General Information |
Reference  |
|---|
    2.7.8.41 | metabolism |
cardiolipin synthase in liver mitochondria increases significantly in rats treated with thyroxine. Control cardiolipin synthase activity is 22.4 pmol/mg*h versus 34.1 pmol/mg*h in thyroxine-treated liver mitochondria |
727056 |
| 2.7.8.41 | malfunction |
a yeast mutant with a deletion of YDL142c is defective in the formation of cardiolipin. A cls1 deletion strain is viable on glucose, galactose, ethanol, glycerol and lactate containing media, although the growth rate on nonfermentable carbon sources is decreased. Mitochondria of the cls1 mutant are devoid of cardiolipin but accumulate the cardiolipin precursor phosphatidylglycerol when grown on nonfermentable carbon sources |
-, 727498 |
| 2.7.8.41 | physiological function |
cardiolipin synthase is involved in maintaining physiologic membrane structure and function even under metabolic stress |
727909 |
| 2.7.8.41 | physiological function |
the enzyme catalyzes the terminal step in cardiolipin biosynthesis. Cardiolipin is essential for mitochondrial structure and function |
728087 |
| 2.7.8.41 | malfunction |
null mutant can grow on both fermentable and non-fermentable carbon sources at lower temperatures, it cannot form colonies at 37°C |
-, 728313 |
| 2.7.8.41 | physiological function |
expression of CRD1 is essential for normal colony formation at elevated temperatures |
-, 728313 |
| 2.7.8.41 | malfunction |
overexpression of clsA results in weakened hyphal tips, misshaped aerial hyphae and anucleate spores and demonstrates that cardiolipin synthesis is a requirement for morphogenesis in Streptomyces |
-, 728326 |
| 2.7.8.41 | physiological function |
cardiolipin synthesis is a requirement for morphogenesis in Streptomyces |
-, 728326 |
| 2.7.8.41 | malfunction |
in contrast to yeast, where development of deletion mutants is little affected, the Arabidopsis seedlings are slow developing under short-day conditions in vitro and die if they are transferred to long-day conditions |
728476 |
| 2.7.8.41 | physiological function |
the enzyme is crucial for correct mitochondrial function and development in Arabidopsis under both optimal and stress conditions |
728476 |
