Any feedback?
Please rate this page
(search_result.php)
(0/150)

BRENDA support

Refine search

Search General Information

show results
Don't show organism specific information (fast!)
Search organism in taxonomic tree (slow, choose "exact" as search mode, e.g. "mammalia" for rat,human,monkey,...)
(Not possible to combine with the first option)
Refine your search

Search term:

Results 1 - 2 of 2
download as CSV
download all results as CSV
EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 2.6.1.37malfunction gene phnW, encoding 2-aminoethylphosphonate:pyruvate aminotransferase, exhibits reduced expression in the oxyR mutant compared to wild-type bacteria. A phnW mutant is more susceptible to tert-butyl-hydroperoxide (t-BOOH) treatment than wild-type bacteria. This may be due to a reduced efficiency for this strain to degrade t-BOOH relative to wild-type organisms because of modulation of AHP gene transcription in the phnW mutant. Provision of the phnW gene in trans can also protect a strain lacking AhpC and Ohr proteins (ohr ahpC mutant), that have previously been shown to be highly susceptible to organic hydroperoxides including t-BOOH. The phnW mutant degrades only 55% of the t-BOOH compared to the 80% degradation observed in wild-type bacteria at the end of assay -, 760032
Display the reaction diagram Show all sequences 2.6.1.37physiological function the OxyR-regulated phnW gene encoding enzyme 2-aminoethylphosphonate:pyruvate aminotransferase helps protect Pseudomonas aeruginosa from tert-butyl hydroperoxide. The LysR member of bacterial transactivators, OxyR, governs transcription of genes involved in the response to H2O2 and organic (alkyl) hydroperoxides (AHP) in the Gram-negative pathogen, Pseudomonas aeruginosa. Analysis of binding of OxyR to the phnW promoter, binding sequence determination, overview. The enzyme PhnW influences the degradation of tert-butyl-hydroperoxide (t-BOOH), but purified does not show a direct ability to degrade t-BOOH in vitro. Tert-butyl-hydroperoxide can cause apoptosis -, 760032
Results 1 - 2 of 2
download as CSV
download all results as CSV