EC Number   |
General Information |
Reference |
|---|
   2.4.1.102 | evolution |
in contrast to cellular homologues, this virus has evolved to alternatively express two proteins from gene Bo17 |
-, 736713 |
| 2.4.1.102 | evolution |
the enzyme belongs to the GT14 family |
735958 |
| 2.4.1.102 | evolution |
the viral 17 gene encodes a functional homologue of the cellular Corebeta1,6GnT typeM(C2GnT-M), which was acquired from a recent ancestor of the African buffalo. Bo17 splicing is conserved among BoHV-4 strains but not in its cellular counterparts |
759690 |
| 2.4.1.102 | malfunction |
a Bo17 knockout strain does not display any growth deficit in vitro. But sole expression of either of the two Bo17-encoded proteins could influence BoHV-4 growth |
-, 736713 |
| 2.4.1.102 | malfunction |
aberrant GCNT3 expression is associated with increased mucin production, aggressive tumorigenesis, and reduced patient survival, and CRISPR-mediated knockout of GCNT3 in pancreatic cancer cells reduces proliferation and spheroid formation. Inhibitor talniflumate alone and in combination with low-dose gefitinib reduced GCNT3 expression, leading to the disrupted production of mucins in vivo and in vitro |
735883 |
| 2.4.1.102 | malfunction |
C2GnT2 deficiency, impair of mucosal barrier, increase of susceptibility to colitis, reduced immunoglobulin abundance, loss of all core 4 O-glycan biosynthetic activity |
705696 |
| 2.4.1.102 | malfunction |
C2GnT3 deficiency, reduced thyroxine levels in circulation |
705696 |
| 2.4.1.102 | malfunction |
Gcnt1-/-Th1 cells lacking C2-GlcNAcT-I expression show impaired P-lig expression similar to Fut4+7-/-Th1 cells. In contrast to impaired P-lig expression,Gcnt1-/-and Fut4 +7-/- maintain their inflammatory competence as assessed by IFNgamma expression. Functional relevance of Gcnt1 deficiency in CD4+T cells in vivo. In line with a lack of Gcnt1 transcription, naive T cells exhibit a closed histone configuration with lowH3K4me2 and prominent H3K27me3 marks. The active H3K4me2 mark in this region increases in a time-dependent manner during Th1 differentiation |
759781 |
| 2.4.1.102 | malfunction |
GCNT1-overexpressing cells produce a significantly larger amount of growth factors when cocultured with prostate stromal cells compared with GCNT1-knocked down cells and form larger tumors |
735617 |
| 2.4.1.102 | malfunction |
GCNT3 overexpression reduces 5-fluorouracil resistance in colorectal cancer (CRC) cells. GCNT3 overexpression reduces proliferation, invasion and changes metabolic capacities of CRC cells. The enzyme's overexpression in epithelial ovarian cancer (EOC) patients is associated with better clinical outcome and response to initial therapy |
760171 |
