EC Number   |
General Information |
Reference |
|---|
    1.2.1.79 | evolution |
sequence analysis of AbSSADH reveals its high degree of sequence similarity to other enzymes in the two-cysteine GabD family |
763015 |
| 1.2.1.79 | evolution |
SSADH belongs to the aldehyde dehydrogenase (ALDH) superfamily |
-, 742844 |
| 1.2.1.79 | evolution |
SSADH belongs to the aldehyde dehydrogenase (ALDH) superfamily, which is a kind of NAD(P)+-dependent oxidoreductase using a wide range of aldehydes as its substrate |
763137 |
| 1.2.1.79 | malfunction |
both R121A and R457A variants are almost inactive, demonstrating a key role of each arginine in catalysis |
763578 |
| 1.2.1.79 | metabolism |
enzyme catalyzes the last step of the gamma-aminobutyrate degradation |
-, 724115 |
| 1.2.1.79 | metabolism |
Sp2771 enzyme completes together with a novel 2-oxoglutarate decarboxylase a non-canonical tricarboxylic acid cycle |
725838 |
| 1.2.1.79 | metabolism |
SSADH plays an essential role in the metabolism of the inhibitory neurotransmitter c-aminobutyric acid |
-, 710394 |
| 1.2.1.79 | metabolism |
succinic semialdehyde dehydrogenase from Synechococcus is an essential enzyme in the tricarboxylic acid cycle of cyanobacteria |
725523 |
| 1.2.1.79 | metabolism |
SySSADH catalyzes one of the NAD(P)H generating reactions in the oxidative TCA cycle. The oxidative TCA cycle is a pathway with low efficiency in NADPH generation in Synechocystis sp. 6803. Similar to isocitrate dehydrogenase from Synechocystis sp. 6803, SySSADH specifically catalyzes the NADPH-generating reaction and is not inhibited by citrate. To avoid NADPH overproduction, the oxidative pentose phosphate (OPP) pathway dehydrogenase activity is repressed when the flow of the oxidative TCA cycle increases in Synechocystis sp. 6803. Metabolic map around the OPP pathway, overview |
762707 |
| 1.2.1.79 | metabolism |
the enzyme is involved in the GABA shunt pathway, GABA shunt reactions from glutamate to succinate might appear in cytosol in addition to mitochondria making the GABA shunt pathway much more diverse |
763578 |
