EC Number   |
General Information |
Reference |
|---|
   1.18.1.2 | drug target |
the cytotoxicity of heteroaromatic N-oxides in murine hepatoma MH22a and human colon carcinoma HCT-116 cells increases with the geometric average of their reactivity towards NADPH:cytochrome P-450 reductase and Plasmodium falciparum ferredoxin:NADP+ oxidoreductase, and with their reactivity towards rat NQO1 |
764913 |
| 1.18.1.2 | evolution |
NfnA architecturally belongs to the Fnr family, while NfnB is a member of a disulfide oxidoreductase superfamily |
742880 |
| 1.18.1.2 | evolution |
the enzyme is a member of the flavoprotein superfamily |
-, 743411 |
| 1.18.1.2 | metabolism |
FNR catalyzes the last step of the linear electron transfer chain in chloroplasts. But FNR also functions in the crossing of various electron transfer pathways |
714333 |
| 1.18.1.2 | metabolism |
FNR mediates the final step of photosynthetic electron flow by transferring electrons from ferredoxin to NADP+ |
700751 |
| 1.18.1.2 | metabolism |
function in ferric iron metabolism |
-, 698606 |
| 1.18.1.2 | metabolism |
the enzyme also drives the Fenton reaction |
721788 |
| 1.18.1.2 | metabolism |
the enzyme has a function in utilizing any excess reducing power of NADPH |
743478 |
| 1.18.1.2 | metabolism |
the petH gene encoding ferredoxin:NADP+ oxidoreductase has two translation products depending on growth conditions and leading to two isoforms. Under standard conditions where FNRL accumulates, two transcriptional start points are found at -52 and -34 relative to the first translation start site. Under nitrogen-starvation conditions where FNRS accumulates a transcriptional start point is mapped at -126 relative to the first translation start site. Therefore, the transcript responsible for FNRS translation is longer than that producing FNRL |
728323 |
| 1.18.1.2 | more |
chloroplast proteins Tic62 and TROL anchor the enzyme to the thylokoid membrane. Tic62-FNR complexes are not directly involved in photosynthetic reactions, but Tic62 protects FNR from inactivation during the dark periods. TROL-FNR complexes have an impact on the photosynthetic performance of the plants |
714333 |
