EC Number   |
General Information |
Reference |
|---|
   1.17.99.9 | malfunction |
cox15 mutants are blocked in heme A but not heme O biosynthesis |
759188 |
| 1.17.99.9 | malfunction |
overexpression of a non-functional mutant causes a reduction in heme A content. This hindrance in the heme A synthesis provokes a reduction on CcO activity and, in consequence, an impairment on Trypanosoma cruzi survival, proliferation and infectivity |
-, 758753 |
| 1.17.99.9 | metabolism |
heme O hydroxylation, catalyzed by Cox15p is an important regulatory step |
759189 |
| 1.17.99.9 | metabolism |
the enzyme is involved in biosynthesis of heme A |
-, 758779 |
| 1.17.99.9 | metabolism |
the enzyme is involved in biosynthesis of heme A, an obligatory cofactor in eukaryotic cytochrome c oxidase. The enzyme catalyses the conversion of heme o to heme a by two successive hydroxylations of the methyl group at C-8, using water as the oxygen source. The first hydroxylation forms heme i, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme a |
-, 758775, 758778 |
| 1.17.99.9 | metabolism |
the enzyme is involved in heme A biosynthesis |
759424 |
| 1.17.99.9 | metabolism |
the enzyme is required for heme A biosynthesis |
-, 758929, 759467 |
| 1.17.99.9 | physiological function |
the COX15 protein is essential for the assembly of yeast cytochrome oxidase |
759454 |
| 1.17.99.9 | physiological function |
the enzyme is required for starvation survival, recovery, and cytochrome biosynthesis |
-, 759426 |
