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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.1.3.38metabolism identification of a gated entry and exit path at the subunit interface of VAO for small phenolic ligands. The residues Met192, Met195 and Glu464 form a portal in this path. Residues His466 and Tyr503 act as concierges, obstructing the path to the active site for phenolic substrates once substrate is bound. An additional, different entry and exit path for dioxygen and hydrogen peroxide at the interface of the two domains of VAO exists. Tyr51 in this path could assist reduced flavin oxidation in VAO 763609
Display the word mapDisplay the reaction diagram Show all sequences 1.1.3.38metabolism tyrosine residues Tyr-108 and Tyr-503 are positioned to facilitate deprotonation of substrate's phenol groups. The reduction of VAOA by chavicol or vanillyl alcohol occurs at two different rates: kobs1, which corresponds to its reaction with the deprotonated form of the substrate, and kobs2, which corresponds to its reaction with the protonated form of the substrate. In mutants Y108F, Y503F, and Y108F/Y503F, the relative contribution of kobs2 to the reduction is larger than in wild-type VAOA 763252
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