EC Number   |
General Information |
Reference |
|---|
   1.1.3.21 | malfunction |
the glpD mutant strain GPM52 (glpD gene disrupted between nucleotides 555 and 556, resulting in a truncated protein of 185 amino acids) does not grow at all in glycerol-containing medium |
-, 698631 |
| 1.1.3.21 | metabolism |
glycerol is one of the few carbon sources that can be utilized by Mycoplasma pneumoniae. Glycerol metabolism involves uptake by facilitated diffusion, phosphorylation, and the oxidation of glycerol 3-phosphate to dihydroxyacetone phosphate, a glycolytic intermediate. Glycerol metabolism is important for cytotoxicity of Mycoplasma pneumoniae with the enzyme being important but not essential, overview |
-, 698631 |
| 1.1.3.21 | physiological function |
GlpO is involved in production and translocation of toxic H2O2 into the host cell, causing inflammation and cell death |
-, 713579 |
| 1.1.3.21 | physiological function |
the formation of hydrogen peroxide by GlpD is crucial for cytotoxic effects of Mycoplasma pneumoniae. The glycerol 3-phosphate oxidase encoded by glpD is essential for glycerol utilization |
-, 698631 |
