EC Number   |
General Information |
Reference |
|---|
    1.1.1.51 | drug target |
the ratio of HSD17B1 to HSD17B2 is a good indicator of tamoxifen treatment benefit, as post-menopausal patients with tumors expressing a high HSD17B1/HSD17B2 protein ratio have less benefit from tamoxifen treatment |
762074 |
| 1.1.1.51 | evolution |
3,17beta-hydroxysteroid dehydrogenase is a member of the short-chain dehydrogenase/reductase (SDR) superfamily |
-, 740307 |
| 1.1.1.51 | evolution |
all three proteins (Rdh11/12-like 1-3) include conserved signatures of the SDR family, such as cofactor binding (TGXXXGXG), the catalytic mechanism (YXXXK), and the structural integrity (NVG or NAG) patterns. Japanese eel Rdh11/12-like 1 clusters with piscine Rdh11 and Rdh12, but the cluster is formed outside that of mammalian Rdh11 and Rdh12. In contrast, Rdh11/12-like 2 and Rdh11/12-like 3 form a clade with putative European eel Rdh11s and Rdh12s outside that of mammalian and piscine Rdh11/Rdh12 |
761195 |
| 1.1.1.51 | evolution |
enzyme AKR1C35 is a member of the aldoketo reductase (AKR) 1C subfamily in the AKR superfamily |
740637 |
| 1.1.1.51 | evolution |
enzyme Tsol-17betaHSD belongs to the short-chain dehydrogenase/reductase (SDR) protein superfamily, it shares motifs and activity with the type 3 enzyme of some other species |
740501 |
| 1.1.1.51 | evolution |
the enzyme belongs to the AKR1C family |
740329 |
| 1.1.1.51 | malfunction |
AKR1C3 siRNA reduces androgen receptor signaling in VCaP cells. Small-molecule inhibitors inhibit both the enzymatic and coactivator functions of AKR1C3 resulting in androgen-dependent prostate cancer and CRPC regression |
740329 |
| 1.1.1.51 | malfunction |
compared to the wild-type Comamonas testosteroni, degradation ability of testosterone and cholesterol is almost lost, and degradation of estradiol is decreased in the 3,17beta-HSD knockout mutant. Degradation of testosterone and cholesterol is obviously increased in the 3,17beta-HSD overexpression mutant. The growths in the medium with testosterone, cholesterol or estradiol are impaired in 3,17beta-HSD knockout mutant |
-, 740292 |
| 1.1.1.51 | malfunction |
knockdown of 17beta-HSD1 gene, HSD17B1, modulates the transcript profile of the hormone-dependent breast cancer cell line T47D, T47D, with 105 genes regulated 1.5 fold or higher in estradiol-independent manner |
761900 |
| 1.1.1.51 | malfunction |
knockdown of 17beta-HSD1 gene, HSD17B1, modulates the transcript profile of the hormone-dependent breast cancer cell line T47D, with 105 genes regulated 1.5fold or higher in estradiol-independent manner. Genes that are primarily involved in the cell cycle progression, such as the cyclin A2 gene, CCNA2, are generally down-regulated whereas genes involved in apoptosis and cell death, including the pro-apoptotic gene XAF1, IFIH1 and FGF12, are upregulated by 17beta-HSD1 knockdown |
761900 |
