EC Number   |
General Information |
Reference |
|---|
   4.1.99.14 | physiological function |
spore photoproduct lyase repairs a covalent UV-induced thymine dimer, spore photoproduct, in germinating endospores and is responsible for strong UV resistance of endospores |
-, 727020 |
| 4.1.99.14 | physiological function |
spore photoproduct lyase repairs a special thymine dimer 5-thyminyl-5,6-dihydrothymine, which is commonly called spore photoproduct at the bacterial early germination phase. Spore photoproduct is the exclusive DNA photo-damage product in bacterial endospores. Its generation and swift repair by the enzyme are responsible for the spores' extremely high UV resistance |
-, 727074 |
| 4.1.99.14 | physiological function |
the overwhelming majority of DNA photoproducts in UV-irradiated spores is a unique thymine dimer called spore photoproduct, SP, or 5-thymine-5,6-dihydrothymine. This lesion is repaired by the spore photoproduct lyase enzyme that directly reverts 5-thymine-5,6-dihydrothymine to two unmodified thymines. The SP lyase enzyme demonstrates an aspect of the diversity of DNA repair mechanisms in living organisms |
680685 |
| 4.1.99.14 | physiological function |
the radical SAM enzyme, spore photoproduct lyase, requires an H-atom transfer (HAT) pathway to catalyze DNA repair |
-, 747506 |
| 4.1.99.14 | physiological function |
UV radiation triggers the formation of 5-thyminyl-5,6-dihydrothymine, i.e., the spore photoproduct (SP), in the genomic DNA of bacterial endospores. These SPs, if not repaired in time, may lead to genome instability and cell death. SP is mainly repaired by spore photoproduct lyase (SPL) during spore outgrowth via an unprecedented protein-harbored radical transfer pathway that is composed of at least a cysteine and two tyrosine residues. 5-thyminyl-5,6-dihydrothymine, i.e. the spore photoproduct (SP), is the dominant DNA photolesion found in bacterial endospores |
-, 747837 |
