EC Number   |
General Information |
Reference |
|---|
   3.5.1.B15 | physiological function |
pyrazinamide (PZA) is an important component of first-line anti-tuberculosis (anti-TB) drugs. The anti-TB agent is activated into an active form, pyrazinoic acid, by Mycobacterium tuberculosis (MTB) pncA gene encoding pyrazinamidase (PZase) |
757258 |
| 3.5.1.B15 | physiological function |
pyrazinamide (PZA) is an important component of first-line antituberculosis drugs activated by Mycobacterium tuberculosis pyrazinamidase (PZase) into its active form pyrazinoic acid (PZA) |
-, 757293 |
| 3.5.1.B15 | physiological function |
role of flap region present in PncA protein in development of resistance to the drug, molecular dynamics simulations |
-, 756295 |
| 3.5.1.B15 | physiological function |
the mycobacterial enzyme pyrazinamidase (PZase), is the target of pyrazinamide (PZA), one of the first-line medications for treatment of tuberculosis. PZA is a prodrug catalyzed to its active form pyrazinoic acid (POA) by enzyme PZase. POA is pumped out of the cell slowly and converts to its conjugate acid form to easily diffuse inwards and accumulates |
-, 757291 |
| 3.5.1.B15 | physiological function |
the reaction product pyrazinoic acid inhibits Mycobacterium tuberculosis type I fatty acid synthase, represses mycolic acid biosynthesis, and appears to affect membrane energetics and acidification of the cytoplasm |
710862 |
