EC Number   |
General Information |
Reference |
|---|
   1.3.99.1 | more |
succinate dehydrogenase forms the peripheral part of the Succinate-ubiquinone oxidoreductase, EC 1.3.5.1, and is composed of a flavoprotein, SdhA, and an iron-sulfur protein, SdhB |
-, 713193 |
| 1.3.99.1 | more |
the catalytic core Sdh1 and Sdh2 subunits contain the redox cofactors that participate in electron transfer to ubiquinone. Sdh1 contains the covalently bound FAD cofactor and the binding site for succinate. Sdh2 contains the three Fe-S centers that mediate electron transfer to ubiquinone in the complex of succinate-ubiquinone dehydrogenase, EC 1.3.5.1, regulation of SDH, overview. The Leigh syndrome, also known as subacute necrotizing encephalomyelopathy, is an early-onset progressive neurodegenerative disorder, associated with impaired SDH activity due to mutations, e.g. G555E, mechanism of the disease, overview. Mutations in SDHB,-C, and -D are asscoiated with tumor formation, overview |
712976 |
| 1.3.99.1 | more |
the I subunit contains three well-conserved cysteine-rich clusters associated with the iron-sulfur centers involved in electron transport |
-, 725299 |
| 1.3.99.1 | physiological function |
role of calcium cations in the mechanism of phytochrome-dependent regulation of the sdh1-2 gene expression and succinate dehydrogenase activity in maize leaves, overview. Higher content of calcium cations in the nucleus correlates with the lower level of the sdh1-2 gene transcription, regulation, overview |
724250 |
| 1.3.99.1 | physiological function |
SDH catalyzes the oxidation of succinate to fumarate in the matrix of the mitochondrion, donating electrons to ubiquinone that subsequently enter into the electron transport chain |
712582 |
| 1.3.99.1 | physiological function |
SDH is located in the inner membrane of mitochondria and its activity is connected with the operation of the electron transport chain, where it functions as a succinate:ubiquinone reductase, EC 1.3.5.1 |
712018 |
| 1.3.99.1 | physiological function |
succinate dehydrogenase is part of the nonoxidative branch of the TCA cycle and is directly linked to the respiratory chain. This enzyme complex catalyzes the oxidation of succinate to fumarate, donating FADH2 for oxidative phosphorylation |
-, 712296 |
