EC Number   |
Expression |
Reference |
|---|
   1.3.99.23 | down |
in adipocytes down-regulated in obesity |
700994 |
| 1.3.99.23 | more |
effect of retinol on gene expressions in P-19 cells, overview |
725598 |
| 1.3.99.23 | more |
major transcriptional regulators of RetSat are the nuclear peroxisome proliferator-activated receptor alpha (PPARalpha) in organs such as liver and PPARgamma in adipose tissue through a PPAR-response element (PPRE) in intron 1 of the human genes |
763769 |
| 1.3.99.23 | more |
major transcriptional regulators of RetSat are the nuclear peroxisome proliferator-activated receptor alpha (PPARalpha) in organs such as liver and PPARgamma in adipose tissue through a PPAR-response element (PPRE) in intron 1 of the murine genes |
763769 |
| 1.3.99.23 | up |
forkhead box O1 (FOXO1), a transcription factor under the control of insulin that regulates gluconeogenesis, shows binding near to the Retsat gene in mouse liver and transactivates its expression in primary hepatocytes. Retsat is also expressed in stem cells and is regulated by zinc-finger protein X-linked (Zfx). Zfx deletion in embryonic and hematopoietic stem cells of mice reduced Retsat mRNA expression. RetSat mRNA and protein expression is robustly upregulated during the differentiation of white pre-adipocytes of murine origin |
763769 |
| 1.3.99.23 | up |
incubation of mature adipocytes with pioglitazone or the non-thiazolidinedione ligand GW7845 increases RetSat mRNA expression, peroxisome proliferator activated receptor gamma, PPARgamma, is required for RetSat expression in mature adipocytes |
700994 |
| 1.3.99.23 | up |
major transcriptional regulators of RetSat expression include peroxisome proliferator-activated receptor alpha (PPARalpha) and forkhead box O1 (FoxO1) in liver, and PPARgamma in adipose tissue, where RetSat's expression is robustly induced during the differentiation of precursor cells into adipocytes |
763507 |
| 1.3.99.23 | up |
RetSat mRNA and protein expression is robustly upregulated during the differentiation of white pre-adipocytes of human origin |
763769 |
