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1.17.99.9
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transcription of COX15 is positively regulated by by Hap1, a transcription factor whose activity is positively controlled by intracellular heme concentration. While COX15 mRNA levels increase with increasing intracellular heme levels in the presence of Hap1, the mRNA levels of COX15 are depressed and independent of intracellular heme levels in the absence of Hap1
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