EC Number   |
Reaction |
Reference |
|---|
   4.1.1.64 | 2,2-dialkylglycine + pyruvate = dialkyl ketone + CO2 + L-alanine |
cooperativity does not play a role in catalysis or regulation |
4753 |
| 4.1.1.64 | 2,2-dialkylglycine + pyruvate = dialkyl ketone + CO2 + L-alanine |
kinetics of inhibition |
650109 |
| 4.1.1.64 | 2,2-dialkylglycine + pyruvate = dialkyl ketone + CO2 + L-alanine |
kinetics, a rate-limiting, concerted Calpha-decarboxylation/c4-protonation mechanism for the AIB decarboxylation reaction and rapid equilibrium quinoid formation followed by rate-limiting protonation to the ketimine intermediate for the L-alanine transamination half-reaction |
650033 |
| 4.1.1.64 | 2,2-dialkylglycine + pyruvate = dialkyl ketone + CO2 + L-alanine |
mechanism |
4756, 652809 |
| 4.1.1.64 | 2,2-dialkylglycine + pyruvate = dialkyl ketone + CO2 + L-alanine |
model in which the interaction between a carboxylate group in the B subsite and Arg406 is a prerequisite to proton donation to and removal from Calpha |
4754 |
| 4.1.1.64 | 2,2-dialkylglycine + pyruvate = dialkyl ketone + CO2 + L-alanine |
pH-studies on the mechanism |
4756 |
| 4.1.1.64 | 2,2-dialkylglycine + pyruvate = dialkyl ketone + CO2 + L-alanine |
the reaction of the slower substrates L-phenylglycine and 1-aminocyclohexane-1-carboxylate may have external aldimine formation as the rate-determining step. The biphasic reactions of 2-methyl-2-aminomalonate, 1-aminocyclopentane-1-carboxylate, isopropylamine and Gly all have external aldimine formation as the rapid observable step |
4755 |
