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EC Number	Reaction	Commentary	Reference
2.7.7.45	2 GTP = diphosphate + P1,P4-bis(5'-guanosyl) tetraphosphate	mechanism	643338, 643341
2.7.7.45	2 GTP = diphosphate + P1,P4-bis(5'-guanosyl) tetraphosphate	ping-pong kinetics with a covalent enzyme-guanylate intermediate containing a phosphoramidate linkage, probably phospholysine	643339
2.7.7.45	2 GTP = diphosphate + P1,P4-bis(5'-guanosyl) tetraphosphate	the alpha-phosphorus group of the GMP of the covalent reaction intermediate is linked via the Nepsilon2 ring nitrogen of a histidine residue of the enzyme	643341, 643342

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Release 2023.1 (January 2023)