EC Number |
Reaction |
Reference |
---|
1.1.1.93 | tartrate + NAD+ = oxaloglycolate + NADH + H+ |
A-side dehydrogenase, i.e. the hydride is transferred from the substrate to the pro-R position of C4 of NADH |
389612 |
1.1.1.93 | tartrate + NAD+ = oxaloglycolate + NADH + H+ |
kinetic mechanism, equilibrium-ordered addition of Mn2+ prior to D-malate or meso-tartrate, overview |
667741 |
1.1.1.93 | tartrate + NAD+ = oxaloglycolate + NADH + H+ |
lysyl amino group, Lys192 is the base responsible for the water-mediated proton abstraction from the C2 hydroxyl group of the substrate that begins the catalytic reaction, followed by hydride transfer to NAD. The hydroxyl group of Tyr141 functions as a general acid to protonate the enolate intermediate. Each substrate undergoes the initial hydride transfer |
710720 |
1.1.1.93 | tartrate + NAD+ = oxaloglycolate + NADH + H+ |
primarily ordered mechanism |
389618 |