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EC Number Posttranslational Modification Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.6.4.B10phosphoprotein InR/PI3K/Akt network in Drosophila dynamically phosphorylates sbunit CCT8 in response to insulin stimulation 757875
Display the word mapDisplay the reaction diagram Show all sequences 3.6.4.B10ubiquitination VRK2 is important for the eukaryotic chaperonin TRiC protein degradation pathway and is involved in polyQ protein aggregation. Ubiquitin-specific protease 25 (USP25) is a VRK2 substrate that acts on TRiC deubiquitination. USP25 deubiquitinates TRiC subunit CCT4. TRiC ubiquitination is induced by inhibition of USP25 and E3 ligase COP1 is recruited. Subsequently, TRiC protein levels are decreased. USP25 knockdown enhances CCT4 polyubiquitination and reduces CCT4 protein levels 757660
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