EC Number   |
Posttranslational Modification |
Reference |
|---|
    2.3.1.50 | glycoprotein |
the small activating subunits of serine palmitoyltransferase, ssSPTs, are glycoproteins and are part of the enzyme complex |
736411 |
| 2.3.1.50 | more |
carrier lipid during extraction required for activity |
487164 |
| 2.3.1.50 | no glycoprotein |
- |
487166 |
| 2.3.1.50 | phosphoprotein |
phosphorylation of serine palmitoyltransferase long chain-1 (SPTLC1) on tyrosine 164 by the fusion kinase ABL inhibits the SPTLC1 enzyme activity. ABL-mediated phosphorylation of SPTLC1 affects its endoplasmic reticulum localization |
736416 |
| 2.3.1.50 | phosphoprotein |
phosphorylation of serine palmitoyltransferase long chain-1 (SPTLC1) on tyrosine 164 by the fusion kinase BCR-ABL inhibits the SPTLC1 enzyme activity. Inhibition of BCR-ABL kinase using either imatinib or shRNA-mediated silencing leads to the activation of SPTLC1 and to increased apoptosis in both K562 and LAMA-84 cells. ABL-mediated phosphorylation of SPTLC1 affects its endoplasmic reticulum localization |
736416 |
| 2.3.1.50 | phosphoprotein |
the enzyme is phosphorylated at S284 regulating its substrate specificity |
736888 |
