EC Number |
Posttranslational Modification |
Reference |
---|
2.7.11.15 | phosphoprotein |
GRK2 is phosphorylated by c-Src kinase, ERK1 and ERK2, protein kinase C, and PKA, overview |
661455 |
2.7.11.15 | phosphoprotein |
GRK2 is phosphorylated by MAP kinase at S670 |
661202 |
2.7.11.15 | phosphoprotein |
GRKs are regulated by phopshorylation |
677258 |
2.7.11.15 | phosphoprotein |
phosphorylated at Ser670 |
724779 |
2.7.11.15 | phosphoprotein |
phosphorylation, e.g. by PKA, PKC, ERK1/2 or c-SRC, activates the enzyme |
672408 |
2.7.11.15 | phosphoprotein |
regulation of GRKs by other kinases, such as PKA, PKC, ERK1 and ERK2, e.g. GRK2 is phosphorylated at Ser670 by ERK1 or ERK2, phosphorylation of the beta-adrenergic receptor-activated GRK2 by c-SRC at tyrosine residues mediated by binding of beta-arrestin, which rapidly activates the GPCR phosphorylation activity of GRK2 and its degradation via the ubiquitine/proteosome pathway, overview |
662911 |