EC Number   |
Application |
Reference |
|---|
   4.1.2.9 | biofuel production |
overexpression of the PktB isoform leads to a 2fold increase in intracellular acetyl-CoA concentration, and a 2.6fold yield enhancement from methane to microbial biomass and lipids compared to wild-type, increasing the potential for methanotroph lipid-based fuel production |
-, 748556 |
| 4.1.2.9 | biotechnology |
expression of bacterial phosphoketolase in Saccharomyces cerevisiae (that does not demonstrate efficient phosphoketolase activity naturally) can efficiently divert intracellular carbon flux toward C2-synthesis, thus showing potential to be used in metabolic engineering strategies aimed to increase yields of acetyl-CoA derived compounds |
746713 |
| 4.1.2.9 | biotechnology |
pathway engineering advances in a high-potential alternative route, the phosphoketolase pathway, which facilitates bypass of pyruvate decarboxylation and enables complete carbon conservation in bioprocesses targeting pentose phosphate pathway and/or acetyl-CoA-derived products |
-, 747624 |
| 4.1.2.9 | industry |
industrially important enzyme in the production of L-glutamic acid, mevalonate, isoprenoid precursors and isoprene |
746964 |
| 4.1.2.9 | industry |
the production of D-lactic acid as well as L-lactic acid is of significant importance for the practical application of polylactic acid, which is an important raw material for bioplastics that can be produced from biomass |
-, 701818 |
| 4.1.2.9 | industry |
using the Lactobacillus plantarum NCIMB 8826 strain whose L-lactate dehydrogenase gene is deficient and whose phosphoketolase gene is substituted with a heterologous transketolase gene the fermentation of optically pure D-lactic acid from arabinose is achieved |
-, 701801 |
| 4.1.2.9 | pharmacology |
polyketide natural products play an important role in the treatment of a wide range of human physiological disorders |
690561 |
| 4.1.2.9 | synthesis |
a phosphoketolase disruption mutant harboring the pXylRAB gene for catabolism of xylose lacks the phosphoketolasepathwas pathway and produces predominantly lactic acid from xylose via the pentose phosphate pathway, although its fermentation rate slightly decreases. Further introduction of the transketolase gene to disrupted phosphoketolase locus leads to restoration of the fermentation rate. As a result, the strain produces 50.1 g/l of L-lactic acid from xylose with a optical purity of 99.6% and a yield of 1.58 mol per mole xylose consumed |
726756 |
| 4.1.2.9 | synthesis |
expression of mutant T2A/I6T/H260 in Corynebacterium glutamicum Z188 results in 16.67% and 18.19% improvement in L-glutamate titer and yield, respectively, compared with the wildtype |
762660 |
| 4.1.2.9 | synthesis |
given that acetyl-CoA is a key intermediate in several biosynthetic pathways, phosphoketolase overexpression offers a viable strategy to enhance the economics of an array of biological methane conversion processes |
-, 748556 |
